Resources Center
From Bench to Production - Scaling Up Cell Culture with Confidence
Scaling up bioprocesses presents challenges, as variations in cell culture conditions can affect product consistency and yield. This can put pressure on downstream processing, risking product quality. Understanding bioreactor dynamics is crucial for reliable operation.
MixIT 4.2 Release
Tridiagonal Solutions Inc. is pleased to announce the release of MixIT 4.2, a unique tool designed to evaluate stirred tank mixing. MixIT helps in analyzing and predicting the mixing process using advanced 3D CFD models and empirical correlations. It provides insights to solve scale-up problems and reduce uncertainties during tech transfer. The intuitive and streamlined interface facilitates chemi...
MixIT – Runs in the Cloud
Another great advancement for batch mixing. Now you can access MixIT™ from virtually any remote location. The Tridiagonal Solutions team has made MixIT more user-friendly by installing it on the Cloud for its customers to leverage remote accessibility.
Scale-up of bi-phasic fast competitive oxidation reaction
Many reactions like oxidation, halogenation, nitration, Grignard, pH adjustment as part of work-up and product isolation etc can be very fast reactions in which the reaction rate is faster or comparable with the mixing rate. Typically, fast reactions are associated with competitive side reactions and hence scale-up of these reactions needs to be based on detailed mixing analysis. Fast competitive ...
MixIT on Cloud: Cloud-based Mixing Simulation Software | Mixing Analysis Anytime, Anywhere
In the Chemical and Pharmaceutical Industry, Right First Time Scale up can significantly speed up the time to market and reduce costs of trials and hence product development. A vast majority of chemical products are made in stirred tanks. It is crucial to build up a reliable process and choose the correct equipment so that you meet your product quality attributes. Further, lowering down batch wast...
Mixing analysis for successful scale-up of Crystallization Processes
Effective scale-up of crystallization processes relies heavily on proficient mixing techniques. Improper mixing can lead to detrimental outcomes such as oiling out, agglomeration, and unstable Metastable Zone Width (MZW), significantly impacting nucleation and growth kinetics.
Leverage Mixing Analysis for Right-first-time Scale-up Success
Understanding and addressing the complexities of scale-up in chemical processes poses significant challenges for researchers and engineers alike. From liquid-liquid heterogeneous fast oxidation reactions to low occupancy antisolvent crystallization processes, each stage demands meticulous attention to detail to ensure successful replication and transfer from lab to production scale.
Maximize Business Impact Of Modeling & Simulations
In today's chemical, pharma, and biotech industries, computational modeling and simulation (M&S) play a pivotal role in process development. Despite its accuracy in predicting intricate flow dynamics and mass transfer, the full potential of M&S remains untapped. One significant hurdle is the lack of accessibility to simulation data and insights for non-M&S engineers, resulting in waste...
The Power of Simulations: How to Harness Data for Informed Decision-Making
In the dynamic landscape of decision-making, data takes center stage. However, challenges such as incomplete data, prolonged decision timelines, and resource loss due to delays are significant hurdles. This is where simulations come into play – a strategic approach empowering decision-makers to test scenarios, assess outcomes, and make informed choices.
Asset Characterization: Digital Nameplating of Assets
Asset characterization is an important step in determining the process performance capability of a given unit operations equipment. As we saw in an earlier post, it forms the backbone of process understanding and science-driven development/transfer. Lets recap things a bit here: Asset characterization can be performed conveniently using computational/first-principles models. This results in a digi...
“Oriflame” talks about MixIT
One of the Top 50 Cosmetic Brands – Oriflame talks about how Tridiagonal Solutions flagship product MixIT helped them explore the untapped potential of CFD modelling of mixing in stirred tank reactors in the Cosmetic Industry Space.
Tridiagonal Solutions launches PERMiT
It helps with design and operation of oil and gas pipelines within acceptable erosion limits. PERMiT assists in predicting and evaluating the erosion rates for various pipeline components that are prone to erosion using industry accepted erosion models, field data and lab data. The intuitive and streamlined interface makes it easy for design engineers and field operators to analyze various scenari...
MixIT 3.2 Release
MixIT 3.2 Release – Featured Central Database System, Enhanced User Based Access with Multiphase Simulations.