Resources Center
Boiler/Turbine Efficiency
Boiler and Turbine Efficiency is a critical factor in optimizing energy usage in distillery and food & beverage manufacturing operations. Boilers are the primary source of steam for various processes such as distillation, evaporation, and sterilization, while turbines often convert excess steam into electrical energy or mechanical power. Enhancing the efficiency of these systems ensures reduce...
Unlocking Biopharma Productivity: How SimSight Ensures Process Optimization
In today’s competitive biopharma landscape, innovation and speed are crucial. For teams working on process optimization, R&D, and scale-up, balancing efficiency with precision is essential for staying ahead. Whether you’re accelerating time-to-market or optimizing production yield, the tools that support your workflows can make a tremendous difference. That’s where SimSight comes in—designed t...
Scale-Up of Cell Cultures : Impact of Bioreactor Environment
Growing mammalian cell cultures in bioreactors is a complex activity - scaling up such cultures must consider both biological and engineering aspects. Cell lines, when they are grown in shake-flasks, exhibit growth characteristics that are vastly different from those observed when such cultures are grown in agitated bioreactors. It would almost seem like the cells somehow “know” that they need to ...
MixIT 4.2 Release
Tridiagonal Solutions Inc. is pleased to announce the release of MixIT 4.2, a unique tool designed to evaluate stirred tank mixing. MixIT helps in analyzing and predicting the mixing process using advanced 3D CFD models and empirical correlations. It provides insights to solve scale-up problems and reduce uncertainties during tech transfer. The intuitive and streamlined interface facilitates chemi...
MixIT – Runs in the Cloud
Another great advancement for batch mixing. Now you can access MixIT™ from virtually any remote location. The Tridiagonal Solutions team has made MixIT more user-friendly by installing it on the Cloud for its customers to leverage remote accessibility.
Scale-up of bi-phasic fast competitive oxidation reaction
Many reactions like oxidation, halogenation, nitration, Grignard, pH adjustment as part of work-up and product isolation etc can be very fast reactions in which the reaction rate is faster or comparable with the mixing rate. Typically, fast reactions are associated with competitive side reactions and hence scale-up of these reactions needs to be based on detailed mixing analysis. Fast competitive ...
MixIT on Cloud: Cloud-based Mixing Simulation Software | Mixing Analysis Anytime, Anywhere
In the Chemical and Pharmaceutical Industry, Right First Time Scale up can significantly speed up the time to market and reduce costs of trials and hence product development. A vast majority of chemical products are made in stirred tanks. It is crucial to build up a reliable process and choose the correct equipment so that you meet your product quality attributes. Further, lowering down batch wast...
Mixing analysis for successful scale-up of Crystallization Processes
Effective scale-up of crystallization processes relies heavily on proficient mixing techniques. Improper mixing can lead to detrimental outcomes such as oiling out, agglomeration, and unstable Metastable Zone Width (MZW), significantly impacting nucleation and growth kinetics.
Leverage Mixing Analysis for Right-first-time Scale-up Success
Understanding and addressing the complexities of scale-up in chemical processes poses significant challenges for researchers and engineers alike. From liquid-liquid heterogeneous fast oxidation reactions to low occupancy antisolvent crystallization processes, each stage demands meticulous attention to detail to ensure successful replication and transfer from lab to production scale.
Maximize Business Impact Of Modeling & Simulations
In today's chemical, pharma, and biotech industries, computational modeling and simulation (M&S) play a pivotal role in process development. Despite its accuracy in predicting intricate flow dynamics and mass transfer, the full potential of M&S remains untapped. One significant hurdle is the lack of accessibility to simulation data and insights for non-M&S engineers, resulting in waste...
From Bench to Production - Scaling Up Cell Culture with Confidence
Scaling up bioprocesses presents challenges, as variations in cell culture conditions can affect product consistency and yield. This can put pressure on downstream processing, risking product quality. Understanding bioreactor dynamics is crucial for reliable operation.
The Power of Simulations: How to Harness Data for Informed Decision-Making
In the dynamic landscape of decision-making, data takes center stage. However, challenges such as incomplete data, prolonged decision timelines, and resource loss due to delays are significant hurdles. This is where simulations come into play – a strategic approach empowering decision-makers to test scenarios, assess outcomes, and make informed choices.
Process Metrics: The Keystone of Process Understanding
Process metrics or PMs, are characteristics of a pharmaceutical process that are critical to ensuring product quality and process performance. They are characteristics of the processing ‘micro-environment’ for a given unit operations equipment or ‘process asset’. Generally speaking, maintaining these CPMs at the same (or nearly same) values across scales is a necessary condition for maintaining pr...
Asset Digitalization
Asset characterization is an important step in determining the process performance capability of a given unit operations equipment. As we saw in an earlier post, it forms the backbone of process understanding and science-driven development/transfer. Lets recap things a bit here: Asset characterization can be performed conveniently using computational/first-principles models. This results in a digi...
Process Signatures: How can you stop worrying & start loving Scale Up
Process signatures capture the scale-independent relationships for a given unit operation or unit process. They represent scale-up or transfer rules that can be used to seamlessly move processes from one equipment to another, from site to another etc. Process signatures are based on the tenet that achieving process similarity is the same as achieving similarity in the processing environment (insid...
Fundamental Understanding of Pharma Process
Pharma processes are among the more complex processes in the chemical industry. Over the past decade or so, the traditional “quality-by-testing” approach of trial-and-error is being consciously replaced, partly or fully, by a more scientific approach across all aspects of pharmaceutical engineering – discovery, development and manufacturing. This “Quality by Design (QbD)” paradigm – which is a ris...
Asset Characterization: Digital Nameplating of Assets
Asset characterization is an important step in determining the process performance capability of a given unit operations equipment. As we saw in an earlier post, it forms the backbone of process understanding and science-driven development/transfer. Lets recap things a bit here: Asset characterization can be performed conveniently using computational/first-principles models. This results in a digi...
Asset Characterization with Interactive Webapps
Webapps are a great tool to create an interactive interface to visualizing the interaction of Process Parameters (PP), Process Metrics (PM) and Quality Attributes (QA). Let’s say we have a database of assets with it’s credential information and operating parameters. Next step is to access the information in an organized form, and an interactive webapp will help us exactly do that! We will explore ...
“Oriflame” talks about MixIT
One of the Top 50 Cosmetic Brands – Oriflame talks about how Tridiagonal Solutions flagship product MixIT helped them explore the untapped potential of CFD modelling of mixing in stirred tank reactors in the Cosmetic Industry Space.
Tridiagonal Solutions launches PERMiT
It helps with design and operation of oil and gas pipelines within acceptable erosion limits. PERMiT assists in predicting and evaluating the erosion rates for various pipeline components that are prone to erosion using industry accepted erosion models, field data and lab data. The intuitive and streamlined interface makes it easy for design engineers and field operators to analyze various scenari...
MixIT 3.2 Release
MixIT 3.2 Release – Featured Central Database System, Enhanced User Based Access with Multiphase Simulations.