A leading biopharma company faced significant challenges during technology transfer involving mammalian cell culture processes across sites using single-use bioreactors of varying volumes. With only a limited number of batches available for optimization, achieving consistent viable cell density (VCD) across scales became a critical concern. To address this, tech experts at Tridiagonal Software applied a science-driven approach focused on key parameters such as hydrodynamics, mixing efficiency, and mass transfer to identify optimal operating conditions across bioreactor scales. This enabled the company to reduce experimental iterations, accelerate process scale-up, and minimize risk during tech transfer.
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